Latent Effects of Stevens Johnson Syndrome (SJS) / Toxic Epidermal Necrolysis (TEN)

Our law firm has an extensive network of national highly qualified physicians and scientists who are familiar with the serious side effects of Stevens Johnson Syndrome (SJS) / Toxic Epidermal Necrolysis (TEN).

In qualifying cases, our firm provides referrals to medical experts for analysis of the potential latent effects of the disease.

IVIG treatment has shown to reverse the immunological cascade that promotes the spread of Stevens Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN).

Meticulous wound care also reduces the morbidity and mortality associated with these diseases.

The Stevens Johnson Syndrome Foundation (Julie Foundation for allergic drug reactions) is a non profit organization that operates solely through donations.

SJS Fact Sheet SJS/TEN Photos Julie's Story

Eye Information Patient Resources Medical Information

Pharma News

Information about FDA-approved brand name and generic prescription and over-the-counter human drugs and biological therapeutic products.

Drugs@FDA includes most of the drug products approved since 1939. The majority of patient information, labels, approval letters, reviews, and other information are available for drug products approved since 1998.

American Burn Association

Potentially Life-Threatening Skin Diseases

That Should Be Treated at Burn Centers

• Stevens Johnson Syndrome (SJS): this potentially deadly skin disease is almost exclusively the result of an adverse reaction to medication. The reaction is severe, with rash and blisters covering much of the body. Due to the severity of the resulting injury and risk of infection, which can include lifelong negative effects to both internal and external parts of the body, immediate treatment at a burn unit is often warranted.

• Toxic Epidermal Necrolysis (TEN): visibly similar to Stevens Johnson Syndrome (SJS), a Toxic Epidermal Necrolysis (TEN) diagnosis occurs when approximately 30% of the body is covered in rash and blisters. Stevens Johnson Syndrome SJS/TENs symptoms can begin with symptoms such as aching, fever, or headache. These symptoms may be followed by a rash that spreads across the body.

The rash often turns into blisters, which migrate together to separate the skin from the body. In severe cases, the skin begins to slough off and peel away, leaving the body exposed to infection.

The entire body can be affected, as well as the eye area and mucosal membranes.
Stevens Johnson Syndrome SJS/TEN reactions resemble burn injuries. As a result, patients who suffer these adverse drug reactions are susceptible to the same complications as burn patients; most notably, infections that seize on the lack of protection of the body which results from the loss of skin.

For these reasons , Stevens Johnson Syndrome SJS/TENs cases are best treated in a hospital burn center where they can receive medical care from burn specialists. The dedicated multidisciplinary team at the UCH Burn Center is especially equipped to care for patients with skin diseases such as Stevens Johnson Syndrome SJS/TENs with advanced treatments such as amniotic membrane transplant to help preserve eyesight.

EuroScar

EuroSCAR 2008-allopurinol "Results of this multinational study (EuroSCAR) revealed that allopurinol is the drug most commonly associated with Stevens Johnson Syndrome (SJS) or Toxic Epidermal Necrolysis (TEN).  The incidence of allopurinol-associated Stevens Johnson Syndrome (SJS) or Toxic Epidermal Necrolysis (TEN) has increasedpossibly because of increased use and dosages of this drug." ( J Am Acad Dermatol 2008;58:25-32.) See Abstract.

The Severe Cutaneous Adverse Reactions watched over in the study are classified according to the following criteria : One of the essential problem of the case-control study about Toxic Epidermal Necrolysis and Stevens- Johnson Syndrome is the definition of the borders between these two affections and between Stevens-Johnson Syndrome and Erythema Multiforme.

During the international meeting on October,1990, it appeared that the classification should be determined essentially according to the percentage of skin detachment and the semiology of the typical individual "Erythema Multiforme like lesions". Although they are nearly constant, the mucosal lesions were not regarded as a criterion of classification. The review of the Stevens Johnson Syndrome (SJS) cases revealed pictures rather different by "targets" semiology. The distinction between these pictures could be significant on the assumption of distinct causes

Drug Association Meetings

The RegiSCAR project dedicated to severe cutaneous adverse reactions.

Main task of the project is to establish a scientific network of people interested in severe cutaneous adverse dug reactions (SCARs) like Stevens-Johnson syndrome /toxic epidermal necrolysis (SJS/TEN)...