Common offending medicines

 

Motrin Stevens Johnson Syndrome Trial Opens

The lawsuit was brought by Christopher Trejo, 22, over allegations he developed Stevens Johnson Syndrome from Dilantin Cerebellar Atrophy Risks Motrin he took for a fever.

According to his attorney, said the Daily Breeze, Trejo suffers from decreased strength as a result of the sometimes-deadly disorder.

The case is being heard in a Los Angeles Superior Court. Trejo lawyer also discussed peeling skin and adverse reactions to Trejo eyes, organs, and genitals due to toxic epidermal necrolysis aka Lyell's Syndrome” said the Daily Breeze.

Trejo had to abandon plans for medical school, cannot taste or smell, have normal sexual relations, and perform routine bodily functions. Stevens Johnson Syndrome is a severe sensitivity reaction that can be caused by a number of drugs and leaves the patient with blistering of mucous membranes, especially of the mouth, eyes, and genitals, as well as patchy rashes that cause skin peeling. The condition can spread to internal organs and can cause scarring and blindness.

When over 30 percent of the body is impacted, the condition becomes toxic epidermal necrolysis (TEN). Both Stevens Johnson Syndrome and TEN typically call for hospital burn unit treatment.


Sanmarkan AD, Sori T, Thappa DM, Jaisankar TJ.

Retrospective analysis of Stevens-Johnson syndrome and toxic epidermal necrolysis over a period of 10 years. Indian J Dermatol 2011 [cited 2012 Feb 16];56:25-9. Available from: http://www.e-ijd.org/text.asp?2011/56/1/25/77546

Background: Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN), are the acute emergencies in dermatology practice. Prompt diagnosis and management may reduce the morbidity and mortality in SJS/TEN patients.

Early identification of the offending drug is necessary for early withdrawal and to prevent the recurrences of such a devastating illness.

Aims : To study the demography, offending agents, clinical and laboratory features, treatment, complications, morbidity and mortality of SJS/TEN in our hospital. Materials and Methods: In this retrospective study, we reviewed the medical records of SJS, TEN, SJS/TEN overlap of inpatients over a period of 10 years

Results: Maximum number of SJS/TEN cases were in the age group of 11-30 years. Males predominated in the SJS group with a ratio of 1.63:1, whereas females predominated the TEN group with a ratio of 1:2.57.

Nonsteroidal anti-inflammatory drugs (NSAIDs) were the commonest group of drugs among the SJS group in 5/21 patients (23.8%). Antimicrobials were the commonest group of drugs causing TEN in 11/25 patients (44%). Mucosal lesions preceded the onset of skin lesions in nearly 50%. Our study had one patient each of SJS/TEN due to amlodipine and Phyllanthus amarus, an Indian herb.

The most common morbidity noted in our study was due to ocular sequelae and sepsis leading to acute renal failure respectively. Kaposi's varicelliform eruption was found in three of our patients.

Conclusion: Antimicrobials and NSAIDS are the common offending agents of SJS/TEN in our study.