Stevens-Johnson Syndrome
Stevens-Johnson Syndrome
Medical Authorities
Numerous pharmaceutical drugs cause Stevens-Johnson Syndrome (SJS) and TEN. In order to best represent its clients, our firm has acquired scientific databases which identify the majority of the adverse event reports associated with drugs that have a causal nexus with SJS and TEN.
Stevens Johnson Syndrome Foundation
www.sjsupport.org/
Pharma News
Information about FDA-approved brand name and generic prescription and over-the-counter human drugs and biological therapeutic products.
Drugs@FDA includes most of the drug products approved since 1939. The majority of patient information, labels, approval letters, reviews, and other information are available for drug products approved since 1998.
American Burn Association
• Toxic Epidermal Necrolysis (TEN): visibly similar to Stevens-Johnson Syndrome (SJS), a TEN diagnosis occurs when approximately 30% of the body is covered in rash and blisters. Stevens-Johnson Syndkrome / Toxic Epidermal Necrolysis can begin with symptoms such as aching, fever, or headache. These symptoms may be followed by a rash that spreads across the body. The rash often into blisters, which migrate together to separate the skin from the body. In severe cases, the skin begins to slough off and peel away, leaving the body exposed to infection.
The entire body can be affected, as well as the eye area and mucosal membranes.
Stevens-Johnson Syndrome / Toxic Epidermal Necrolysis reactions resemble burn injuries. As a result, patients who suffer these adverse drug reactions are susceptible to the same complications as burn patients; most notably, infections that seize on the lack of protection of the body which results from the loss of skin.
For these reasons Stevens-Johnson Syndrome SJS / Toxic Epidermal Necrolysis TENs cases are best treated in a hospital burn center where they can receive medical care from burn specialists. The dedicated multidisciplinary team at the UCH Burn Center is specially equipped to care for patients with skin diseases such as SJS/TENs with advanced treatments such as amniotic membrane transplant to help preserve eyesight.
EuroScar
EuroSCAR 2008-allopurinol "Results of this multinational study (EuroSCAR) revealed that allopurinol is the drug most commonly associated with Stevens-Johnson Syndrome or Toxic Epidermal Necroylsis. The incidence of allopurinol-associated Stevens-Johnson Syndrome or Toxic Epidermal Necrolysis has increased possibly because of increased use and dosages of this drug." ( J Am Acad Dermatol 2008;58:25-32.) See Abstract.
The Severe Cutaneous Adverse Reactions watched over in the study are classified according to the following criteria : One of the essential problem of the case-control study about Toxic Epidermal Necrolysis and Stevens-Johnson Syndrome is the definition of the borders between these two affections and between Stevens-Johnson Syndrome and Erythema Multiforme.
During the international meeting on October,1990, it appeared that the classification should be determined essentially according to the percentage of skin detachment and the semiology of the typical individual "Erythema Multiforme like lesions". Although they are nearly constant, the mucosal lesions were not regarded as a criterion of classification. The review of the Stevens-Johnson Syndrome cases revealed images rather different by "targets" semiology. The distinction between these images could be significant on the assumption of distinct causes.
Drug Association Meetings
Main task of the project is to establish a scientific network of people interested in severe cutaneous adverse dug reactions (SCARs) like Stevens-Johnson syndrome /toxic epidermal necrolysis (SJS/TEN),...
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