Naprosyn can cause Stevens Johnson Syndrome


Naprosyn / Naproxen Naprosyn

Manufacturer: Roche Naproxen is in a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs), and is primarily used to reduce pain, inflammation, and stiffness caused by many conditions, such as osteoarthritis, rheumatoid arthritis, gout, ankylosing spondylitis (arthritis and stiffness of the spine), injury, abdominal cramps associated with menstruation, tendinitis, and bursitis.

• Data from large long-term controlled clinical trials that have included a comparison of COX-2 selective and non-selective NSAIDs do not clearly demonstrate that the COX-2 selective agents confer a greater risk of serious adverse CV events than non-selective NSAIDs.

Skin Reactions
NSAIDs, including Naproxen Tablets, USP, can cause serious skin adverse events such as exfoliative dermatitis, Stevens-Johnson Syndrome (SJS), and toxic epidermal necrolysis (TEN), which can be fatal. These serious events may occur without warning.


2006 Jun;45(6):709-12.

Naproxen-induced lichen planus: report of 55 cases.

Güneş AT, Fetil E, Ilknur T, Birgin B, Ozkan S.


Department of Dermatology, Faculty of Medicine, University of Dokuz Eylül, Izmir, Turkey.



Clinical and histopathological differential diagnosis is usually impossible in drug-induced lichen planus (LP) and idiopathic LP. Naproxen is a nonsteroidal anti-inflammatory drug, which is widely used for its analgesic, antipyretic and anti-inflammatory effects. To the best of our knowledge, two case reports on naproxen-induced LP have been reported.


Fifty-five patients with LP, and a history of naproxen intake before their eruption, were investigated.


Twenty-five patients (45.5%) had a history of naproxen intake prior to their eruption without any other medication. Twelve patients (21.8%) had a history of simultaneous use of naproxen with other drugs that were reported as inducers of LP. Eighteen patients (32.7%) had given a history of using naproxen together with drugs that had not been previously reported as inducers of LP. Moreover, in 42 patients, eruptive-type LP development after naproxen intake, is an interesting observation. New lesions were not observed after the cessation of naproxen intake in any of the patients.


Naproxen might be accepted as an important inducer for LP, especially for the eruptive form.



Painful Confusion: Many Unaware of OTC Pain Relievers' Ingredients, Risks (American Journal of Preventive Medicine, 5/11)
A poll reveals many Americans don’t know the active ingredients or potential side effects of popular Dilantin Cerebellar Atrophy Risks pain medicines. Tylenol contains acetaminophen, Bayer contains aspirin, Advil and Motrin contain ibuprofen, and Aleve contains naproxen sodium. ...