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Epilepsy  Drugs May Raise
Fracture Risk in Older Adults

In a Canadian study, medications indicated for epilepsy increased the risk of
bone fractures in elderly patients. Researchers analyzed the medical records
of 15,792 people 50 years of age and older who had non-traumatic fractures between
1996 and 2004. ... of epilepsy drugs, including carbamazepine (Carbatrol, Tegretol),
clonazepam (Klonopin), ethosuximide (Zarontin), gabapentin (Neurontin),
phenobarbital (Luminal), phenytoin (Dilantin), and valproic acid (Depakene,

All but one of the drugs (valproic acid) was associated with an increased risk for
fractures. Phenytoin and carbamazepine were associated with the highest risk.
The results were similar for people taking just one epilepsy drug and for
those taking more than one.


Sources: Arch Neurol, January 2011;
Health Day News, January 11, 2011

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